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Presynaptic glutamate release raises glutamate concentrations in the synaptic space to more than 1 mM, and because glutamate is not metabolized extracellularly, it is absorbed by transporters found in astrocytes, including glutamate transporter 1 (GLT-1) and the cysteine/glutamate antiporter (xCT), that act to limit the duration of synaptic action and diffusion of extracellular glutamate (Veruki et al., 2006)

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